Newly Developed Highly Bioavailable Curcumin Formulation, curcuRouge<sup>TM</sup>, Reduces Neutrophil/Lymphocyte Ratio in the Elderly: A Double-Blind, Placebo-Controlled Clinical Trial

Elevated neutrophil/lymphocyte ratio (NLR) has been reported as a sensitive marker for predicting poor prognosis in chronic inflammation-based diseases such stroke, heart failure, cancers, and diabetes, well acute inflammatory bacterial viral infections, including COVID-19. NLR is also known to increase with age considered be an aging marker. We conducted double-blind, placebo-controlled trial elderly volunteers examine the effect of newly developed, highly bioavailable curcumin formulation (curcuRougeTM) on NLR. Both white blood cell count neutrophil rate decreased significantly, lymphocyte increased significantly from baseline after curcuRougeTM administration 4 wk. reduced (p=0.020). On other hand, placebo group, there were no changes count, ratio, or The present study demonstrates first time, volunteers, that reduces NLR, indicator cardiovascular diseases, cancer, infectious aging. Thus, might expected improve these exhibit anti-aging effects.